Set off in a summer heatwave and fanned by strong winds, the fires have destroyed about 40 homes and a five-star hotel in the hills above Funchal, Reuters reported.
On mainland Portugal, thousands of firefighters were still struggling to control hundreds of forest fires - mainly in the north - that have destroyed homes, shut major motorways for hours, and forced the evacuation of several villages this week.
The fire in Funchal was mostly under control, regional governor Miguel Albuquerque told a televised news conference, but several were still raging across the island.
He said 80 people were in hospital suffering from burns and smoke inhalation, including two in a serious condition.
All those killed and injured by the fires were local residents. One person was missing, Albuquerque said.
More than a thousand residents and tourists were sent to makeshift shelters and army barracks during the night although some had been allowed to return since. Two hospitals in the area were also evacuated.