The pro-Palestinian marches are held in capital Tehran and over 1,000 other cities and villages across the country on the last Friday of the holy month of Ramadan.
The demonstration commemorating the International Quds Day in Tehran kicked off at 10 am as people will converge on the University of Tehran from ten different routes.
The keynote speaker in Tehran is Speaker of the Iranian Parliament Mohammad Baqer Qalibaf.
The demonstrators in the capital have hoisted the flags of the resistance and pro-Palestinian groups, such as the Lebanese Hezbollah, Hamas, the Islamic Jihad Movement, Fatemiyoun, Zainebiyoun and Hashd al-Sha'bi.
The International Quds Day is an annual event during which demonstrators express their solidarity with the Palestinian people and opposition to the occupation of the Palestinian territories by the Zionist regime of Israel.
The day is seen as the legacy of the late founder of the Islamic Republic of Iran, Imam Khomeini, who officially declared the last Friday of the holy month of Ramadan as International Quds Day back in 1979.