Many participants came with banners "Trump should go now," "Impeach Trump," and "Stop Trump", a TASS correspondent reported.
Speakers criticized expelling illegal migrants. The demonstrators called the current Washington administration "fascist" and chanted: "Trump must go!"
The action was organized by public organizations, including anti-war, leftist and supportive of migrants.
Trump has repeatedly stated that about 25 million people had entered the country illegally before he came to power, and has advocated stricter immigration policies. After the inauguration, the president introduced a state of emergency on the US border with Mexico.
Trump promised to ensure the largest operation in American history to deport illegal migrants.
Trump's political opponents accuse his administration of overly harsh actions against migrants.